Methodological Issues in Current Antipsychotic Drug Trials

Methodological issues in current antipsychotic drug trials.

Every year numerous reports on antipsychotic drug trials are being published in neuropsychiatric journals, adding new information to our knowledge in the field. The information however is often hard for the reader to interpret, sometimes contradictory to comparable available studies and leaves more questions open than it actually answers. Although the overall quality of the studies is rather go...

Methodological Issues in Estimating Prescription Drug Coverage Using the Medicare Current Beneficiary Survey

Methodological issues in randomized trials assessing probiotics for periodontal treatment.

BACKGROUND AND OBJECTIVE Probiotics traditionally used in medicine field are now being used in an attempt to control and treat periodontal disease. However, the trials used to analyze the effects of probiotics have been subject to methodological criticism. The aim of this review was to assess the methodological deficiencies in randomized controlled trials evaluating the efficacy and safety of o...

Current issues in non-inferiority trials.

Non-inferiority (NI) trials enable a direct comparison of the relative benefit-to-risk profiles of an experimental intervention and a standard-of-care regimen. When the standard has clinical efficacy of substantial magnitude that is precisely estimated ideally using data from multiple adequate and well-controlled trials, with such estimates being relevant to the setting of the NI trial, then th...

AT ISSUE Methodological Issues in Negative Symptom Trials

Stephen R. Marder, David G. Daniel, Larry Alphs, A. George Awad, and Richard S. E. Keefe The Semel Institute for Neuroscience at University of California, Los Angeles and the Desert Pacific Mental Illness Research, Education, andClinical Center, LosAngeles, CA; United BioSource Corporation,Mclean, VA; Ortho-McNeil Janssen Scientific Affairs; University of Toronto and Department of Psychiatry, H...